An octagonal plan inspired by 15C Lombard models with a Bramante matrix is the distinguishing feature of this church. Erected in 1586 and annexed to the Servite convent, it was painted by Clemente Isacci in 1767 with baroque panelling. It contains the funeral monument of Duke Vespasiano Gonzaga Colonna, built by Giovan Battista Della Porta in 1592.

In July 1988, the Duke’s tomb was rediscovered, conserving his bones and those of members of his family. The pendant of the collar of the Golden Fleece was found between Vespasiano’s ribs and is now in the Museo d’Arte Sacra.